HORDB

General Information

ID: hor006062
Uniprot ID: Q99N14
Protein name: Hemokinin
Gene name: Tac4
Organism: Mus musculus (Mouse)
Family: Tachykinin family
Source: Animal
Expression: Expressed in hematopoietic cells with highest levels in pre- and pro-B cells but not in later developmental stages. Also detected in uterus, skeletal muscle, brain, spleen, stomach, skin and lactating mammary gland and in cells of myeloid lineage includin
Disease: NA
Comments: NA
Taxonomy: Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea , Myomorpha (suborder), Rodentia (order), Glires , Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0005102 signaling receptor binding; GO:0031835 substance P receptor binding; GO:0031837 substance K receptor binding; GO:0048018 receptor ligand activity
GO BP: GO:0003085 negative regulation of systemic arterial blood pressure; GO:0006954 inflammatory response; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007217 tachykinin receptor signaling pathway; GO:0008217 regulation of blood pressure; GO:0043303 mast cell degranulation; GO:0046878 positive regulation of saliva secretion; GO:0050965 detection of temperature stimulus involved in sensory perception of pain; GO:0051930 regulation of sensory perception of pain; GO:1902093 positive regulation of flagellated sperm motility; GO:1904057 negative regulation of sensory perception of pain; GO:1904058 positive regulation of sensory perception of pain
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

Sequence: RSRTRQFYGLM
Length: 11(56-66)
Propeptide: MLPLLALLLLIGPSVCTTAGDREELAFGAEAESWVTVNLKGIPVPSIELKLQELKRSRTRQFYGLMGKRVGGYQLGRIVQDLLGTRGLSIEGTCRQAASQQRARPGAVTRESLQSREEDEAPLTTSNV
Signal peptide: MLPLLALLLLIGPSVC
Modification: T11 Methionine amide
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle
Mechanism: NA
Cross BBB: NA
Target: Tacr1
Target Unid: P14600
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: AF-Q99N14-F1(AlphaFold_DB_ID)

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006062_AF2.pdb

hor006062_ESM.pdb

Physical Information

Mass:	159318	Formula:	C61H99N21O16S
Absent amino acids:	ACDEHIKNPVW	Common amino acids:	R
pI:	12.2	Basic residues:	3
Polar residues:	4	Hydrophobic residues:	2
Hydrophobicity:	-106.36	Boman Index:	-4522
Half-Life:	1 hour	Half-Life Yeast:	2 min
Half-Life E.Coli:	2 min	Aliphatic Index	35.45
Instability Index:	9911.82	Extinction Coefficient cystines:	1490
Absorbance 280nm:	149

Literature

PubMed ID: 11062498
Title: Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis.
PubMed ID: 12716968
Title: Characterization of the endokinins: human tachykinins with cardiovascular activity.
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 15489334
Title: The statu
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